L-Ergothioneine is a stable antioxidant that can be found under conditions of excessive oxidative stress in plant and animal tissue. L-ergothioneine has the ability to scavenge free radicals and protect cells from UV-induced ROS with higher efficiency than antioxidants coenzyme Q(10) or idebenone, thus making it more effective antioxidant. 

Reults: Administration of L-egt to diabetic animals reduced serum triglyceride, water intake, MAP, biomarkers of cardiac injury (CK-MB, CRP), lipid peroxidation, and inflammation. Also, Legt increased body weight, antioxidant enzymes, upregulated Nrf2, HO-1, NQO1 expression, and decreased Keap1 expression. The in-silico study showed that L-egt inhibits the Keap1-Nrf2 complex by binding to the active site of Nrf2 protein, thereby preventing its degradation.

Conclusion: L-egt protects against diabetes-induced cardiovascular injury via the upregulation of the Keap1-Nrf2 pathway and its downstream cytoprotective antioxidants.

Keywords: Cardio-protection; L-ergothioneine; cardiovascular disease (CVD).; diabetes; molecular docking; molecular dynamics.

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