Now offering custom senolytic compound development and clinical study services - For endurance athletes, finishing strong is decided at the cellular level: NAD+ powers mitochondrial energy production and post-exercise recovery.
The NAD+ Performance Connection
Nicotinamide adenine dinucleotide (NAD+) is perhaps the most critical molecule for cellular energy production and DNA repair. Training depletes NAD+ pools, and levels decline with age — driving mitochondrial dysfunction, genomic instability, slower recovery, and reduced endurance output. Sirtivatine™ defends and rebuilds them.
Beyond Simple Precursors
While NAD+ precursors like NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) have gained attention, Sirtivatine™ holistically addresses multiple aspects of NAD+ metabolism:
NAD+ Synthesis Enhancement
Our research includes next-generation precursors like NMNH and NRH, which may offer superior bioavailability and cellular uptake compared to traditional options.
NADase Inhibition
Compounds like Apigenin and various Berberine derivatives inhibit CD38 and other NAD±consuming enzymes, preserving NAD+ pools for endurance and recovery.
NAMPT Upregulation
The rate-limiting enzyme in NAD+ salvage pathway, NAMPT, can be upregulated by specific natural compounds, enhancing the body’s ability to recycle NAD+.
Sirtivatine™ Lead Compounds
Astragalin: The Cellular Protector
This flavonoid glycoside not only supports NAD+ levels but also activates sirtuins directly — dual benefits for cellular longevity and training resilience.
Fisetin: The Multi-Target Molecule
Beyond its senolytic properties, fisetin enhances NAD+ biosynthesis and supports mitochondrial function, making it a cornerstone of our formulations.
Pterostilbene: The Enhanced Resveratrol
With superior bioavailability compared to resveratrol, pterostilbene activates sirtuins more effectively while supporting NAD+ metabolism.
Trigonelline: The Coffee Compound
This coffee-bean alkaloid has shown remarkable NAD+-boosting and metabolic-health effects in preclinical studies.
Custom Research Capabilities
Sirtivatine™ offers specialized research services focusing on:
PARP Inhibition Studies
Poly(ADP-ribose) polymerases consume significant amounts of NAD+. Our research identifies natural PARP modulators that balance DNA repair with NAD+ conservation.
SLC25A51 Transport Optimization
This mitochondrial NAD+ transporter is crucial for cellular energy production. We’re developing natural compounds that enhance its function.
Clinical Applications and Biomarkers
Our comprehensive NAD+ assessment includes:
- Cellular NAD+/NADH ratios
- Sirtuin activity measurements
- Mitochondrial function markers
- DNA damage and repair indicators
The Future of NAD+ Therapy
As NAD+ research advances, Sirtivatine™ is positioned to lead sophisticated, multi-target approaches to cellular energy metabolism, mitochondrial output, and healthy aging.
From Cellular Science to Performance
Cellular energy underpins Botanicure’s three strategic platforms: Muscle & Strength, Brain & Cognition, and Sports Performance. By optimizing NAD+ metabolism, Sirtivatine™ gives formulators a science-backed lever for endurance, mitochondrial output, and faster post-exercise recovery — benefits consumers can actually feel in training, competition, and everyday life. Partner with Botanicure to bring next-generation NAD+ ingredients to market and power your next performance launch.